Display Settings:

Format

Send to:

Choose Destination
HomoloGene:37480. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FLNB,  H.sapiens
filamin B, beta
NP_001157789.1
2633 aa
FLNB,  P.troglodytes
filamin B, beta
XP_001174012.2
2633 aa
FLNB,  M.mulatta
filamin B, beta
XP_001097922.2
2632 aa
FLNB,  C.lupus
filamin B, beta
XP_003432942.1
2633 aa
FLNB,  B.taurus
filamin B, beta
NP_001178389.1
2633 aa
Flnb,  M.musculus
filamin, beta
NP_598841.1
2591 aa
Flnb,  R.norvegicus
filamin B, beta
NP_001100758.1
2578 aa
FLNB,  G.gallus
filamin B, beta
NP_001025512.1
2567 aa
flnb,  X.tropicalis
filamin B, beta
XP_004914227.1
2633 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atelostogenesis, type I.
Atelosteogenesis, type III.
Boomerang dysplasia.
Larsen syndrome, autosomal dominant.
Larson syndrome.
Spondylocarpotarsal synostosis syndrome.



Publications
Articles associated with genes and sequences of this homology group.

FLNB-Related Disorders
Robertson S, et al. (1993).
Mutations in two regions of FLNB result in atelosteogenesis I and III.
Farrington-Rock C, et al. Hum Mutat 27, 705-10 (2006).
Phenotype matters.
Biesecker LG. Nat Genet 36, 323-4 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Filamin (pfam00630)
  Filamin/ABP280 repeat.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Filamin (cl19759)
  Filamin/ABP280 repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Flnb includes H.sapiens FLNB and R.norvegicus Flnb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 5 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

Support Center