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HomoloGene:429. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FGG,  H.sapiens
fibrinogen gamma chain
NP_068656.2
453 aa
FGG,  P.troglodytes
fibrinogen gamma chain
XP_001138780.1
437 aa
FGG,  M.mulatta
fibrinogen gamma chain
XP_001089651.1
453 aa
FGG,  C.lupus
fibrinogen gamma chain
XP_005629425.1
445 aa
FGG,  B.taurus
fibrinogen gamma chain
NP_776336.1
444 aa
Fgg,  M.musculus
fibrinogen gamma chain
NP_598623.1
436 aa
Fgg,  R.norvegicus
fibrinogen gamma chain
NP_036691.2
437 aa
FGG,  G.gallus
fibrinogen gamma chain
NP_990320.1
435 aa
fgg,  X.tropicalis
fibrinogen gamma chain
XP_002933524.1
438 aa
fgg,  D.rerio
fibrinogen, gamma polypeptide
NP_998219.1
431 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dysfibrinogenemia, gamma type.
Hypofibrinogenemia, gamma type.
Thrombophilia, dysfibrinogenemic.



Publications
Articles associated with genes and sequences of this homology group.

Zn2+ mediates high affinity binding of heparin to the αC domain of fibrinogen.
Fredenburgh JC, et al. J Biol Chem 288, 29394-402 (2013).
Mechanism of fibrin(ogen) forced unfolding.
Zhmurov A, et al. Structure 19, 1615-24 (2011).
Association between γ' fibrinogen levels and inflammation.
Alexander KS, et al. Thromb Haemost 105, 605-9 (2011).
γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke.
van den Herik EG, et al. Thromb Haemost 105, 430-4 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fib_alpha (pfam08702)
  Fibrinogen alpha/beta chain family.
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgg includes H.sapiens FGG and R.norvegicus Fgg.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 14 species)
Actinopterygii - bony fishes (14 transcripts, 11 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

 

 

 

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