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HomoloGene:428. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

FGA,  H.sapiens
fibrinogen alpha chain
866 aa
FGA,  P.troglodytes
fibrinogen alpha chain
866 aa
FGA,  M.mulatta
fibrinogen alpha chain
889 aa
FGA,  C.lupus
fibrinogen alpha chain
892 aa
Fga,  M.musculus
fibrinogen alpha chain
789 aa
Fga,  R.norvegicus
fibrinogen alpha chain
782 aa
FGA,  G.gallus
fibrinogen alpha chain
741 aa
fga,  X.tropicalis
fibrinogen alpha chain
759 aa
fga,  D.rerio
fibrinogen alpha chain
684 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Amyloidosis, hereditary renal.
Dysfibrinogenemia, alpha type, causing bleeding diathesis.
Dysfibrinogenemia, alpha type, causing recurrent thrombosis.
Afibrinogenemia, congenital.

Articles associated with genes and sequences of this homology group.

Role of fibrinogen in acute ischemic kidney injury.
Sörensen-Zender I, et al. Am J Physiol Renal Physiol 305, F777-85 (2013).
Proteomic profiling of serum from stage I lung squamous cell carcinoma patients.
Li XJ, et al. Asian Pac J Cancer Prev 14, 2273-6 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fib_alpha (pfam08702)
  Fibrinogen alpha/beta chain family.
CTD (smart01104)
  Spt5 C-terminal nonapeptide repeat binding Spt4.
Fibrinogen_aC (pfam12160)
  Fibrinogen alpha C domain.
Fibrinogen_aC (pfam12160)
  Fibrinogen alpha C domain.
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fga includes H.sapiens FGA and R.norvegicus Fga.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)




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