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HomoloGene:56284. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FA2H,  H.sapiens
fatty acid 2-hydroxylase
NP_077282.3
372 aa
FA2H,  P.troglodytes
fatty acid 2-hydroxylase
XP_511106.3
374 aa
FA2H,  M.mulatta
fatty acid 2-hydroxylase
XP_001108607.1
372 aa
FA2H,  C.lupus
fatty acid 2-hydroxylase
XP_853014.1
372 aa
FA2H,  B.taurus
fatty acid 2-hydroxylase
NP_001179384.1
372 aa
Fa2h,  M.musculus
fatty acid 2-hydroxylase
NP_835187.2
372 aa
Fa2h,  R.norvegicus
fatty acid 2-hydroxylase
NP_001129055.1
372 aa
FA2H,  G.gallus
fatty acid 2-hydroxylase
XP_414053.4
540 aa
fa2h,  X.tropicalis
fatty acid 2-hydroxylase
NP_001025677.1
371 aa
fa2h,  D.melanogaster
fatty acid 2-hydroylase
NP_610279.3
355 aa
CELE_C25A1.5,  C.elegans
CELE_C25A1.5
NP_492678.1
316 aa
SCS7,  S.cerevisiae
SCS7
NP_013999.1
384 aa
KLLA0D01639g,  K.lactis
KLLA0D01639g
XP_453142.1
381 aa
AGOS_AAL183W,  E.gossypii
AGOS_AAL183W
NP_982359.1
377 aa
MGG_03920,  M.oryzae
MGG_03920
XP_003719946.1
384 aa
NCU03492,  N.crassa
NCU03492
XP_955879.1
371 aa
FAH1,  A.thaliana
FAH1
NP_181023.1
237 aa
Os03g0780800,  O.sativa
Os03g0780800
NP_001051453.1
237 aa
Os12g0628400,  O.sativa
Os12g0628400
NP_001067329.1
238 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukodystrophy, dysmyelinating, and spastic paraparesis with or without dystonia.



Publications
Articles associated with genes and sequences of this homology group.

Heterozygous FA2H mutations in autism spectrum disorders.
Scheid I, et al. BMC Med Genet 14, 124 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cyt-b5 (pfam00173)
  Cytochrome b5-like Heme/Steroid binding domain.
CYB5 (COG5274)
  Cytochrome b involved in lipid metabolism [Energy production and conversion / Lipid metabolism].
FA_hydroxylase (cl01132)
  Fatty acid hydroxylase superfamily.
FA_hydroxylase (cl01132)
  Fatty acid hydroxylase superfamily.
Cyt-b5 (cl02041)
  Cytochrome b5-like Heme/Steroid binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fa2h includes H.sapiens FA2H and R.norvegicus Fa2h.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (57 transcripts, 32 species)
Liliopsida - monocots (19 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 9 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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