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HomoloGene:9. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SGCA,  H.sapiens
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
NP_000014.1
387 aa
SGCA,  P.troglodytes
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
XP_523792.2
526 aa
SGCA,  M.mulatta
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
XP_001092850.1
387 aa
SGCA,  C.lupus
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
XP_005624692.1
387 aa
SGCA,  B.taurus
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
NP_001013420.1
388 aa
Sgca,  M.musculus
sarcoglycan, alpha (dystrophin-associated glycoprotein)
NP_033187.1
387 aa
Sgca,  R.norvegicus
sarcoglycan, alpha (dystrophin-associated glycoprotein)
NP_001100509.1
387 aa
sgca,  X.tropicalis
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
XP_002935590.2
389 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adhalinopathy, primary.
Muscular dystrophy, limb-girdle, type 2D.



Publications
Articles associated with genes and sequences of this homology group.

Altered functional differentiation of mesoangioblasts in a genetic myopathy.
Altomare C, et al. J Cell Mol Med 17, 419-28 (2013).
Founder mutation for α-sarcoglycan-LGMD2D in a Magdalen Islands Acadian cluster.
Tétreault M, et al. Can J Neurol Sci 38, 747-52 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CA_like (cl15786)
  Cadherin repeat-like domain.
Sarcoglycan_2 (pfam05510)
  Sarcoglycan alpha/epsilon.
CA_like (cl15786)
  Cadherin repeat-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sgca includes H.sapiens SGCA and R.norvegicus Sgca.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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