HomoloGene - NCBI

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HomoloGene:9. Gene conserved in Tetrapoda

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	SGCA, H.sapiens sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			NP_000014.1 387 aa
	SGCA, P.troglodytes sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			XP_523792.2 526 aa
	SGCA, M.mulatta sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			XP_001092850.1 387 aa
	SGCA, C.lupus sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			XP_005624692.1 387 aa
	SGCA, B.taurus sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			NP_001013420.1 388 aa
	Sgca, M.musculus sarcoglycan, alpha (dystrophin-associated glycoprotein)			NP_033187.1 387 aa
	Sgca, R.norvegicus sarcoglycan, alpha (dystrophin-associated glycoprotein)			NP_001100509.1 387 aa
	sgca, X.tropicalis sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)			XP_002935590.2 389 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:600119 Adhalinopathy, primary.
MIM:608099 Muscular dystrophy, limb-girdle, type 2D.

Publications Articles associated with genes and sequences of this homology group.
[A novel missense mutation in the alpha-sarcoglycan gene in a Spanish family with muscular dystrophy]. Pinel-González A, et al. Rev Neurol 56, 590-1 (2013).
Altered functional differentiation of mesoangioblasts in a genetic myopathy. Altomare C, et al. J Cell Mol Med 17, 419-28 (2013).
The first case of primary alpha-sarcoglycanopathy identified in Albania, in two siblings with homozygous alpha-sarcoglycan mutation. Babameto-Laku A, et al. Genet Couns 22, 377-83 (2011).
Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo. Cassano M, et al. Development 138, 4523-33 (2011).
Founder mutation for α-sarcoglycan-LGMD2D in a Magdalen Islands Acadian cluster. Tétreault M, et al. Can J Neurol Sci 38, 747-52 (2011).
Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer. Shimojo H, et al. Prostate 71, 1151-7 (2011).
Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs. Quattrocelli M, et al. J Pathol 223, 593-603 (2011).
Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D. Mendell JR, et al. Ann Neurol 68, 629-38 (2010).
Globular adiponectin as a complete mesoangioblast regulator: role in proliferation, survival, motility, and skeletal muscle differentiation. Fiaschi T, et al. Mol Biol Cell 21, 848-59 (2010).
A common disease-associated missense mutation in alpha-sarcoglycan fails to cause muscular dystrophy in mice. Kobuke K, et al. Hum Mol Genet 17, 1201-13 (2008).
See all (83)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
CA_like (cl15786) Cadherin repeat-like domain.
Sarcoglycan_2 (pfam05510) Sarcoglycan alpha/epsilon.
CA_like (cl15786) Cadherin repeat-like domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:894698 Orthology group for M.musculus Sgca includes H.sapiens SGCA and R.norvegicus Sgca.

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