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HomoloGene:854. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ACLY,  H.sapiens
ATP citrate lyase
NP_001087.2
1101 aa
ACLY,  P.troglodytes
ATP citrate lyase
XP_511495.3
1041 aa
ACLY,  M.mulatta
ATP citrate lyase
XP_001108114.2
1011 aa
ACLY,  C.lupus
ATP citrate lyase
XP_850198.1
1101 aa
ACLY,  B.taurus
ATP citrate lyase
NP_001032534.1
1091 aa
Acly,  M.musculus
ATP citrate lyase
NP_001186225.1
1101 aa
Acly,  R.norvegicus
ATP citrate lyase
NP_058683.2
1101 aa
ACLY,  G.gallus
ATP citrate lyase
NP_001025711.1
1101 aa
acly,  X.tropicalis
ATP citrate lyase
NP_001008028.1
1091 aa
aclya,  D.rerio
ATP citrate lyase a
NP_001002649.1
1092 aa
ATPCL,  D.melanogaster
ATP citrate lyase
NP_725514.2
1095 aa
AgaP_AGAP010156,  A.gambiae
AgaP_AGAP010156
XP_319323.3
1082 aa
acly-2,  C.elegans
acly-2
NP_506267.1
1099 aa
D1005.1,  C.elegans
D1005.1
NP_508280.1
1106 aa
SPBC1703.07,  S.pombe
SPBC1703.07
NP_596202.1
615 aa
MGG_06719,  M.oryzae
MGG_06719
XP_003709430.1
665 aa
NCU06785,  N.crassa
NCU06785
XP_963626.1
670 aa
ACLB-2,  A.thaliana
ACLB-2
NP_199757.1
608 aa
ACLB-1,  A.thaliana
ACLB-1
NP_187317.1
608 aa
Os01g0300200,  O.sativa
Os01g0300200
NP_001042817.1
608 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ATP-citrate lyase is essential for macrophage inflammatory response.
Infantino V, et al. Biochem Biophys Res Commun 440, 105-11 (2013).
ATP citrate lyase knockdown impacts cancer stem cells in vitro.
Hanai JI, et al. Cell Death Dis 4, e696 (2013).
ATP-citrate lyase: a key player in cancer metabolism.
Zaidi N, et al. Cancer Res 72, 3709-14 (2012).
On the catalytic mechanism of human ATP citrate lyase.
Fan F, et al. Biochemistry 51, 5198-211 (2012).
ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.
Sun T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 67, 1168-72 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02235 (PLN02235)
  ATP citrate (pro-S)-lyase.
CoA_binding (pfam02629)
  CoA binding domain.
Ligase_CoA (cl02894)
  CoA-ligase.
ATP-grasp_4 (cl03087)
  ATP-grasp domain.
ATP-grasp_2 (pfam08442)
  ATP-grasp domain.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
ATP-grasp_2 (pfam08442)
  ATP-grasp domain.
CS_ACL-C_CCL (cl00416)
  Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A ...
CoA_binding (cl17356)
  CoA binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Acly includes H.sapiens ACLY and R.norvegicus Acly.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (55 transcripts, 35 species)
Liliopsida - monocots (18 transcripts, 9 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Actinopterygii - bony fishes (24 transcripts, 9 species)
Mammalia - mammals (16 transcripts, 13 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (15 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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