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HomoloGene:7626. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

APAF1,  H.sapiens
apoptotic peptidase activating factor 1
1248 aa
APAF1,  P.troglodytes
apoptotic peptidase activating factor 1
1248 aa
APAF1,  M.mulatta
apoptotic peptidase activating factor 1
1237 aa
APAF1,  C.lupus
apoptotic peptidase activating factor 1
1250 aa
APAF1,  B.taurus
apoptotic peptidase activating factor 1
1238 aa
Apaf1,  M.musculus
apoptotic peptidase activating factor 1
1249 aa
Apaf1,  R.norvegicus
apoptotic peptidase activating factor 1
1249 aa
APAF1,  G.gallus
apoptotic peptidase activating factor 1
1249 aa
apaf1,  X.tropicalis
apoptotic peptidase activating factor 1
330 aa
apaf1,  D.rerio
apoptotic protease activating factor 1
1261 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Changes in Apaf-1 conformation that drive apoptosome assembly.
Yuan S, et al. Biochemistry 52, 2319-27 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CARD_APAF1 (cd08323)
  Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1.
NB-ARC (pfam00931)
  NB-ARC domain.
AAA_16 (pfam13191)
  AAA ATPase domain.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apaf1 includes H.sapiens APAF1 and R.norvegicus Apaf1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (1 transcript, 1 species)




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