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HomoloGene:7090. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GTF2H4,  H.sapiens
general transcription factor IIH, polypeptide 4, 52kDa
NP_001508.1
462 aa
GTF2H4,  P.troglodytes
general transcription factor IIH, polypeptide 4, 52kDa
NP_001038968.1
462 aa
GTF2H4,  M.mulatta
general transcription factor IIH, polypeptide 4, 52kDa
NP_001040607.1
462 aa
GTF2H4,  C.lupus
general transcription factor IIH, polypeptide 4, 52kDa
XP_005627183.1
463 aa
GTF2H4,  B.taurus
general transcription factor IIH, polypeptide 4, 52kDa
NP_001094527.1
463 aa
Gtf2h4,  M.musculus
general transcription factor II H, polypeptide 4
NP_034494.1
463 aa
Gtf2h4,  R.norvegicus
general transcription factor II H, polypeptide 4
NP_997666.1
463 aa
gtf2h4,  X.tropicalis
general transcription factor IIH, polypeptide 4, 52kDa
NP_001015845.1
455 aa
LOC101731871,  X.tropicalis
general transcription factor IIH subunit 4-like
XP_004911969.1
455 aa
gtf2h4,  D.rerio
general transcription factor IIH, polypeptide 4
NP_956221.1
466 aa
mrn,  D.melanogaster
marionette
NP_648780.1
499 aa
AgaP_AGAP010984,  A.gambiae
AgaP_AGAP010984
XP_309710.1
501 aa
TFB2,  S.cerevisiae
TFB2
NP_015203.1
513 aa
KLLA0F01056g,  K.lactis
KLLA0F01056g
XP_455127.1
496 aa
AGOS_ADL274W,  E.gossypii
AGOS_ADL274W
NP_983822.1
514 aa
tfb2,  S.pombe
tfb2
NP_596563.1
447 aa
MGG_00397,  M.oryzae
MGG_00397
XP_003718679.1
490 aa
NCU05523,  N.crassa
NCU05523
XP_960485.2
475 aa
AT4G17020,  A.thaliana
AT4G17020
NP_974564.1
462 aa
Os04g0680000,  O.sativa
Os04g0680000
NP_001054284.1
444 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

New clinico-genetic classification of trichothiodystrophy.
Morice-Picard F, et al. Am J Med Genet A 149A, 2020-30 (2009).
Activation of recombinant trp by thapsigargin in Sf9 insect cells.
Vaca L, et al. Am J Physiol 267, C1501-5 (1994).
Structural basis for group A trichothiodystrophy.
Kainov DE, et al. Nat Struct Mol Biol 15, 980-4 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tfb2 (cl04289)
  Transcription factor Tfb2.
Helicase_C_3 (pfam13625)
  Helicase conserved C-terminal domain.
Tfb2 (cl04289)
  Transcription factor Tfb2.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gtf2h4 includes H.sapiens GTF2H4 and R.norvegicus Gtf2h4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 10 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (23 transcripts, 18 species)
Liliopsida - monocots (6 transcripts, 6 species)
Coniferopsida - conifers (4 transcripts, 3 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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