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HomoloGene:69090. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SLC8A1,  H.sapiens
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_066920.1
973 aa
SLC8A1,  P.troglodytes
solute carrier family 8 (sodium/calcium exchanger), member 1
XP_001137342.1
973 aa
SLC8A1,  M.mulatta
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_001028033.1
934 aa
SLC8A1,  C.lupus
solute carrier family 8 (sodium/calcium exchanger), member 1
XP_005630433.1
1038 aa
SLC8A1,  B.taurus
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_788805.1
970 aa
Slc8a1,  M.musculus
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_035536.2
970 aa
Slc8a1,  R.norvegicus
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_062141.3
970 aa
SLC8A1,  G.gallus
solute carrier family 8 (sodium/calcium exchanger), member 1
NP_001072941.1
969 aa
slc8a1,  X.tropicalis
solute carrier family 8 (sodium/calcium exchanger), member 1
XP_002933933.1
969 aa
slc8a1b,  D.rerio
solute carrier family 8 (sodium/calcium exchanger), member 1b
NP_001034233.1
944 aa
ncx-1,  C.elegans
ncx-1
NP_001041182.1
880 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle.
Yamamura H, et al. Am J Physiol Cell Physiol 305, C299-308 (2013).
The topology of the cardiac Na⁺/Ca²⁺ exchanger, NCX1.
Ren X & Philipson KD. J Mol Cell Cardiol 57, 68-71 (2013).
Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma.
Hilgemann DW, et al. Adv Exp Med Biol 961, 345-52 (2013).
NCX1: mechanism of transport.
Ottolia M & Philipson KD. Adv Exp Med Biol 961, 49-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Calx-beta (pfam03160)
  Calx-beta domain.
Na_Ca_ex (pfam01699)
  Sodium/calcium exchanger protein.
Na_Ca_ex (pfam01699)
  Sodium/calcium exchanger protein.
Calx-beta (cl02522)
  Calx-beta domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc8a1 includes H.sapiens SLC8A1 and R.norvegicus Slc8a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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