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HomoloGene:61. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LYST,  H.sapiens
lysosomal trafficking regulator
NP_000072.2
3801 aa
LYST,  P.troglodytes
lysosomal trafficking regulator
XP_514288.2
3802 aa
LOC718051,  M.mulatta
lysosomal-trafficking regulator-like
XP_002808311.1
3584 aa
LYST,  C.lupus
lysosomal trafficking regulator
XP_005618856.1
3800 aa
LYST,  B.taurus
lysosomal trafficking regulator
NP_776445.1
3796 aa
Lyst,  M.musculus
lysosomal trafficking regulator
NP_034878.2
3787 aa
Lyst,  R.norvegicus
lysosomal trafficking regulator
NP_445970.1
3788 aa
LYST,  G.gallus
lysosomal trafficking regulator
XP_419558.4
3793 aa
lyst,  X.tropicalis
lysosomal trafficking regulator
XP_002935877.2
3736 aa
lyst,  D.rerio
lysosomal trafficking regulator
XP_001919653.2
3886 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Chediak-Higashi syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Chediak-Higashi Syndrome
Toro C, et al. (1993).
Chediak-Higashi syndrome.
Kaplan J, et al. Curr Opin Hematol 15, 22-9 (2008).
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Kisucka J, et al. Proc Natl Acad Sci U S A 103, 855-60 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Beach (cl10511)
  BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lyst includes H.sapiens LYST and R.norvegicus Lyst.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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