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HomoloGene:55946. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HDAC4,  H.sapiens
histone deacetylase 4
NP_006028.2
1084 aa
HDAC4,  P.troglodytes
histone deacetylase 4
XP_003309602.1
1084 aa
HDAC4,  C.lupus
histone deacetylase 4
XP_005635986.1
1083 aa
HDAC4,  B.taurus
histone deacetylase 4
XP_005205100.1
1122 aa
Hdac4,  M.musculus
histone deacetylase 4
NP_997108.1
1076 aa
Hdac4,  R.norvegicus
histone deacetylase 4
NP_445901.1
1077 aa
HDAC4,  G.gallus
histone deacetylase 4
NP_989644.1
1080 aa
hdac4,  X.tropicalis
histone deacetylase 4
XP_004917943.1
1039 aa
hdac4,  D.rerio
histone deacetylase 4
NP_001034447.2
1023 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats.
Usui T, et al. Am J Physiol Heart Circ Physiol 302, H1894-904 (2012).
2q37 Microdeletion Syndrome
Doherty ES, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ClassIIa_HDAC_Gln-rich-N (cl13614)
  Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9).
Arginase_HDAC (cl17011)
  Arginase-like and histone-like hydrolases.
ClassIIa_HDAC_Gln-rich-N (cl13614)
  Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9).
Arginase_HDAC (cl17011)
  Arginase-like and histone-like hydrolases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hdac4 includes H.sapiens HDAC4 and R.norvegicus Hdac4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 5 species)
Mammalia - mammals (10 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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