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HomoloGene:55941. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYH10,  H.sapiens
myosin, heavy chain 10, non-muscle
NP_001242941.1
2007 aa
MYH10,  P.troglodytes
myosin, heavy chain 10, non-muscle
XP_001166541.2
1985 aa
MYH10,  M.mulatta
myosin, heavy chain 10, non-muscle
XP_001118181.2
1999 aa
MYH10,  C.lupus
myosin, heavy chain 10, non-muscle
XP_005620092.1
2077 aa
MYH10,  B.taurus
myosin, heavy chain 10, non-muscle
NP_777259.1
1976 aa
Myh10,  M.musculus
myosin, heavy polypeptide 10, non-muscle
NP_780469.1
1976 aa
Myh10,  R.norvegicus
myosin, heavy chain 10, non-muscle
NP_113708.1
1976 aa
MYH10,  G.gallus
myosin, heavy chain 10, non-muscle
NP_990805.1
2007 aa
LOC100493774,  X.tropicalis
myosin-10-like
XP_004916274.1
2010 aa
myh10,  D.rerio
myosin, heavy chain 10, non-muscle
XP_005165776.1
2006 aa
zip,  D.melanogaster
zipper
NP_523860.2
2056 aa
AgaP_AGAP007523,  A.gambiae
AgaP_AGAP007523
XP_308355.3
2003 aa
nmy-1,  C.elegans
nmy-1
NP_508504.2
1963 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Encodes a 205 kilodalton myosin heavy chain found in Drosophila cell lines and all Drosophila developmental stages. Antibodies raised against this protein crossreact, but weakly with muscle myosin heavy chain. First appears in preblastoderm embryos; diffusely distributed until syncytial blastoderm at which time localization to cortex and pole cells observed; at cleavage furrow, canals at the time of cellularization; transiently present at points of invagination during gastrulation (Young et al., 1987; 1991). (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Enucleation of human erythroblasts involves non-muscle myosin IIB.
Ubukawa K, et al. Blood 119, 1036-44 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
phage_LysB (TIGR03495)
  phage lysis regulatory protein, LysB family.
COG5134 (COG5134)
  Uncharacterized conserved protein [Function unknown].
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
Aldose_epim (cl14648)
  aldose 1-epimerase superfamily.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
DUF342 (cl19219)
  Protein of unknown function (DUF342).
DUF106 (cl19818)
  Integral membrane protein DUF106.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myh10 includes H.sapiens MYH10 and R.norvegicus Myh10.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (40 transcripts, 9 species)
Mammalia - mammals (25 transcripts, 14 species)
Amphibia - amphibians (7 transcripts, 2 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 11 species)
Malacostraca - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Coniferopsida - conifers (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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