Display Settings:


Send to:

Choose Destination
HomoloGene:4313. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SMAD5,  H.sapiens
SMAD family member 5
465 aa
SMAD5,  P.troglodytes
SMAD family member 5
465 aa
SMAD5,  M.mulatta
SMAD family member 5
465 aa
SMAD5,  C.lupus
SMAD family member 5
465 aa
SMAD5,  B.taurus
SMAD family member 5
465 aa
Smad5,  M.musculus
SMAD family member 5
465 aa
Smad5,  R.norvegicus
SMAD family member 5
465 aa
SMAD5,  G.gallus
SMAD family member 5
465 aa
smad5,  D.rerio
MAD homolog 5 (Drosophila)
464 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Genetic polymorphism of SMAD5 is associated with Kawasaki disease.
Cho JH, et al. Pediatr Cardiol 35, 601-7 (2014).
BMP-Smad 1/5/8 signalling in the development of the nervous system.
Hegarty SV, et al. Prog Neurobiol 109, 28-41 (2013).
Alternative splicing of SMADs in differentiation and tissue homeostasis.
Tao S & Sampath K. Dev Growth Differ 52, 335-42 (2010).
Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes.
AnhĂȘ FF, et al. Mol Cell Endocrinol 319, 30-8 (2010).
Smad5 haploinsufficiency leads to hair cell and hearing loss.
Yang SM, et al. Dev Neurobiol 69, 153-61 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MH1 (cl00055)
  N-terminal Mad Homology 1 (MH1) domain.
MH2 (cl00056)
  C-terminal Mad Homology 2 (MH2) domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smad5 includes H.sapiens SMAD5 and R.norvegicus Smad5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)




Support Center