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HomoloGene:41490. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SMURF2,  H.sapiens
SMAD specific E3 ubiquitin protein ligase 2
748 aa
SMURF2,  P.troglodytes
SMAD specific E3 ubiquitin protein ligase 2
748 aa
SMURF2,  M.mulatta
SMAD specific E3 ubiquitin protein ligase 2
901 aa
SMURF2,  C.lupus
SMAD specific E3 ubiquitin protein ligase 2
771 aa
SMURF2,  B.taurus
SMAD specific E3 ubiquitin protein ligase 2
738 aa
Smurf2,  M.musculus
SMAD specific E3 ubiquitin protein ligase 2
748 aa
Smurf2,  R.norvegicus
SMAD specific E3 ubiquitin protein ligase 2
748 aa
SMURF2,  G.gallus
SMAD specific E3 ubiquitin protein ligase 2
753 aa
smurf2,  D.rerio
SMAD specific E3 ubiquitin protein ligase 2
765 aa
lack,  D.melanogaster
lethal with a checkpoint kinase
1061 aa
AgaP_AGAP011242,  A.gambiae
897 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.
Smith MP, et al. J Natl Cancer Inst 105, 33-46 (2013).
Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.
Nakamura M, et al. Neuropathol Appl Neurobiol 37, 307-14 (2011).
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Zhang H, et al. J Cell Physiol 215, 613-20 (2008).
Regulation of embryonic endochondral ossification by Smurf2.
Wu Q, et al. J Orthop Res 26, 704-12 (2008).
Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta.
Ohashi N, et al. FEBS Lett 579, 2557-63 (2005).
Smurf2 up-regulation activates telomere-dependent senescence.
Zhang H & Cohen SN. Genes Dev 18, 3028-40 (2004).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HECTc (cl00077)
  HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
C2 (cl14603)
  C2 domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smurf2 includes H.sapiens SMURF2 and R.norvegicus Smurf2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (14 transcripts, 6 species)
Mammalia - mammals (12 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)




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