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HomoloGene:4133. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

TERF2,  H.sapiens
telomeric repeat binding factor 2
542 aa
TERF2,  P.troglodytes
telomeric repeat binding factor 2
541 aa
TERF2,  M.mulatta
telomeric repeat binding factor 2
528 aa
TERF2,  C.lupus
telomeric repeat binding factor 2
542 aa
TERF2,  B.taurus
telomeric repeat binding factor 2
503 aa
Terf2,  M.musculus
telomeric repeat binding factor 2
540 aa
Terf2,  R.norvegicus
telomeric repeat binding factor 2
497 aa
TERF2,  G.gallus
telomeric repeat binding factor 2
718 aa
terf2,  X.tropicalis
telomeric repeat binding factor 2
471 aa
terfa,  D.rerio
telomeric repeat binding factor a
575 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Recruitment of TRF2 to laser-induced DNA damage sites.
Huda N, et al. Free Radic Biol Med 53, 1192-7 (2012).
Gemcitabine causes telomere attrition by stabilizing TRF2.
Su CH, et al. Eur J Cancer 48, 3465-74 (2012).
[Experiment studies on growth and proliferation of Hep-2 cells by silence of TRF2 gene].
Jiao L, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24, 1131-5 (2010).
Elevated TRF2 in advanced breast cancers with short telomeres.
Diehl MC, et al. Breast Cancer Res Treat 127, 623-30 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TRF2_RBM (cd11654)
  RAP1 binding motif of telomere repeat binding factor.
SANT_TRF (cd11660)
  Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family.
TRFH (cl02779)
  Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Terf2 includes H.sapiens TERF2 and R.norvegicus Terf2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 10 species)
Aves - birds (2 transcripts, 1 species)




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