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HomoloGene:21175. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TRIM28,  H.sapiens
tripartite motif containing 28
NP_005753.1
835 aa
TRIM28,  M.mulatta
tripartite motif containing 28
XP_001098702.2
965 aa
TRIM28,  C.lupus
tripartite motif containing 28
XP_533567.4
837 aa
TRIM28,  B.taurus
tripartite motif containing 28
NP_001193738.1
812 aa
Trim28,  M.musculus
tripartite motif-containing 28
NP_035718.2
834 aa
Trim28,  R.norvegicus
tripartite motif-containing 28
NP_446368.1
835 aa
LOC100489687,  X.tropicalis
transcription intermediary factor 1-beta-like
XP_004916264.1
803 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Clinical utility of KAP-1 expression in thyroid lesions.
Martins MB, et al. Endocr Pathol 24, 77-82 (2013).
TRIM28 prevents autoinflammatory T cell development in vivo.
Chikuma S, et al. Nat Immunol 13, 596-603 (2012).
KAP1 protein: an enigmatic master regulator of the genome.
Iyengar S & Farnham PJ. J Biol Chem 286, 26267-76 (2011).
Functional analysis of KAP1 genomic recruitment.
Iyengar S, et al. Mol Cell Biol 31, 1833-47 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BBC (smart00502)
  B-Box C-terminal domain.
PHD (pfam00628)
  PHD-finger.
BBOX (cl00034)
  B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
BBOX (cl00034)
  B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
PHD (cl17445)
  PHD-finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trim28 includes H.sapiens TRIM28 and R.norvegicus Trim28.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Amphibia - amphibians (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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