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HomoloGene:179. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ITGB4,  H.sapiens
integrin, beta 4
1822 aa
ITGB4,  P.troglodytes
integrin, beta 4
1805 aa
ITGB4,  M.mulatta
integrin, beta 4
1746 aa
ITGB4,  C.lupus
integrin, beta 4
1835 aa
ITGB4,  B.taurus
integrin, beta 4
1751 aa
Itgb4,  M.musculus
integrin beta 4
1802 aa
Itgb4,  R.norvegicus
integrin, beta 4
1807 aa
ITGB4,  G.gallus
integrin, beta 4
1854 aa
itgb4,  X.tropicalis
integrin, beta 4
1770 aa
itgb4,  D.rerio
integrin, beta 4
1893 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Epidermolysis bullosa of hands and feet.
Epidermolysis bullosa, generalized atrophic benign.
Epidermolysis bullosa, junctional, with pyloric atresia.

Articles associated with genes and sequences of this homology group.

Integrin beta4 was downregulated on the airway epithelia of asthma patients.
Liu C, et al. Acta Biochim Biophys Sin (Shanghai) 42, 538-47 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NOA36 (pfam06524)
  NOA36 protein.
Calx-beta (pfam03160)
  Calx-beta domain.
Calx-beta (cl02522)
  Calx-beta domain.
Integrin_beta (pfam00362)
  Integrin, beta chain.
Integrin_B_tail (pfam07965)
  Integrin beta tail domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
SEA (cl02507)
  SEA domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Integrin_beta (cl17693)
  Integrin, beta chain.
Integrin_B_tail (pfam07965)
  Integrin beta tail domain.
EGF_2 (pfam07974)
  EGF-like domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Calx-beta (cl02522)
  Calx-beta domain.
Integrin_beta (cl17693)
  Integrin, beta chain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itgb4 includes H.sapiens ITGB4 and R.norvegicus Itgb4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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