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HomoloGene:898. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

APBB1,  H.sapiens
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NP_001155.1
710 aa
APBB1,  P.troglodytes
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
XP_521814.3
710 aa
APBB1,  C.lupus
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
XP_534037.4
710 aa
APBB1,  B.taurus
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NP_001068654.1
707 aa
Apbb1,  M.musculus
amyloid beta (A4) precursor protein-binding, family B, member 1
NP_001240814.1
710 aa
Apbb1,  R.norvegicus
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NP_536726.1
711 aa
apbb1,  D.rerio
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
XP_005155644.1
712 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Crystal structure of the human Fe65-PTB1 domain.
Radzimanowski J, et al. J Biol Chem 283, 23113-20 (2008).
FE65 interaction with the ApoE receptor ApoEr2.
Hoe HS, et al. J Biol Chem 281, 24521-30 (2006).
A dominant role for FE65 (APBB1) in nuclear signaling.
Yang Z, et al. J Biol Chem 281, 4207-14 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apbb1 includes H.sapiens APBB1 and R.norvegicus Apbb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

 

 

 

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