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HomoloGene:267. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PTH1R,  H.sapiens
parathyroid hormone 1 receptor
NP_001171673.1
593 aa
PTH1R,  P.troglodytes
parathyroid hormone 1 receptor
XP_001152239.1
593 aa
PTH1R,  M.mulatta
parathyroid hormone 1 receptor
XP_001113857.1
593 aa
PTH1R,  C.lupus
parathyroid hormone 1 receptor
NP_001003155.1
595 aa
PTH1R,  B.taurus
parathyroid hormone 1 receptor
NP_001068800.1
589 aa
Pth1r,  M.musculus
parathyroid hormone 1 receptor
NP_001077404.1
591 aa
Pth1r,  R.norvegicus
parathyroid hormone 1 receptor
NP_064458.1
591 aa
PTH1R,  G.gallus
parathyroid hormone 1 receptor
NP_001171046.1
538 aa
LOC100492020,  X.tropicalis
parathyroid hormone/parathyroid hormone-related peptide receptor-like
XP_002939411.2
540 aa
pth1ra,  D.rerio
parathyroid hormone 1 receptor a
NP_571432.1
536 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Metaphyseal chondrodysplasia, Murk Jansen type.
Enchondromatosis, Ollier type.



Publications
Articles associated with genes and sequences of this homology group.

Retromer terminates the generation of cAMP by internalized PTH receptors.
Feinstein TN, et al. Nat Chem Biol 7, 278-84 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HRM (pfam02793)
  Hormone receptor domain.
7tm_2 (pfam00002)
  7 transmembrane receptor (Secretin family).
HRM (cl02422)
  Hormone receptor domain.
GH20_hexosaminidase (cl02948)
  Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. ...
7tm_2 (cl19289)
  7 transmembrane receptor (Secretin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pth1r includes H.sapiens PTH1R and R.norvegicus Pthr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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