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HomoloGene:39748. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SPHK1,  H.sapiens
sphingosine kinase 1
NP_892010.2
470 aa
SPHK1,  P.troglodytes
sphingosine kinase 1
XP_003953242.1
398 aa
LOC710441,  M.mulatta
sphingosine kinase 1-like
XP_001099066.2
551 aa
SPHK1,  C.lupus
sphingosine kinase 1
XP_540448.3
476 aa
SPHK1,  B.taurus
sphingosine kinase 1
XP_002696250.3
475 aa
Sphk1,  M.musculus
sphingosine kinase 1
NP_079643.2
382 aa
Sphk1,  R.norvegicus
sphingosine kinase 1
NP_001257740.1
458 aa
SPHK1,  G.gallus
sphingosine kinase 1
XP_004946176.1
462 aa
sphk1,  X.tropicalis
sphingosine kinase 1
NP_001016918.1
509 aa
LOC100331840,  D.rerio
sphingosine kinase 2-like
XP_002667585.2
342 aa
Sk2,  D.melanogaster
Sphingosine kinase 2
NP_647762.3
661 aa
AgaP_AGAP006995,  A.gambiae
AgaP_AGAP006995
XP_308775.3
627 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.
Ruckhäberle E, et al. J Cancer Res Clin Oncol 139, 1681-9 (2013).
Effect of sphingosine kinase 1 inhibition on blood pressure.
Furuya H, et al. FASEB J 27, 656-64 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DAGK_cat (pfam00781)
  Diacylglycerol kinase catalytic domain.
FAM101 (pfam15068)
  FAM101 family.
DAGK_cat (cl17465)
  Diacylglycerol kinase catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sphk1 includes H.sapiens SPHK1 and R.norvegicus Sphk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (22 transcripts, 19 species)
Liliopsida - monocots (4 transcripts, 3 species)

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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