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HomoloGene:7413. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

MCL1,  H.sapiens
myeloid cell leukemia 1
350 aa
MCL1,  P.troglodytes
myeloid cell leukemia sequence 1 (BCL2-related)
350 aa
MCL1,  M.mulatta
myeloid cell leukemia sequence 1 (BCL2-related)
350 aa
MCL1,  C.lupus
myeloid cell leukemia sequence 1 (BCL2-related)
350 aa
MCL1,  B.taurus
myeloid cell leukemia sequence 1 (BCL2-related)
350 aa
Mcl1,  M.musculus
myeloid cell leukemia sequence 1
331 aa
Mcl1,  R.norvegicus
myeloid cell leukemia sequence 1
330 aa
MCL1,  G.gallus
myeloid cell leukemia sequence 1 (BCL2-related)
335 aa
mcl1a,  D.rerio
myeloid cell leukemia sequence 1a
255 aa
mcl1b,  D.rerio
myeloid cell leukemia sequence 1b
228 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Modulation of Mcl-1 expression reduces age-related cochlear degeneration.
Yang WP, et al. Neurobiol Aging 34, 2647-58 (2013).
Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.
Tripathi P, et al. Cell Death Differ 20, 998-1007 (2013).
Programming cancer cells for high expression levels of Mcl1.
Ertel F, et al. EMBO Rep 14, 328-36 (2013).
The role of Mcl-1 in S. aureus-induced cytoprotection of infected macrophages.
Koziel J, et al. Mediators Inflamm 2013, 427021 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Bcl-2_like (cd06845)
  Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mcl1 includes H.sapiens MCL1 and R.norvegicus Mcl1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (1 transcript, 1 species)




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