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HomoloGene:48134. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EIF2AK2,  H.sapiens
eukaryotic translation initiation factor 2-alpha kinase 2
NP_002750.1
551 aa
EIF2AK2,  P.troglodytes
eukaryotic translation initiation factor 2-alpha kinase 2
NP_001138509.1
552 aa
EIF2AK2,  M.mulatta
eukaryotic translation initiation factor 2-alpha kinase 2
NP_001077417.1
554 aa
EIF2AK2,  C.lupus
eukaryotic translation initiation factor 2-alpha kinase 2
NP_001041600.1
532 aa
EIF2AK2,  B.taurus
eukaryotic translation initiation factor 2-alpha kinase 2
NP_835210.2
533 aa
Eif2ak2,  M.musculus
eukaryotic translation initiation factor 2-alpha kinase 2
NP_035293.1
515 aa
Eif2ak2,  R.norvegicus
eukaryotic translation initiation factor 2-alpha kinase 2
NP_062208.1
513 aa
EIF2AK2,  G.gallus
eukaryotic translation initiation factor 2-alpha kinase 2
NP_989818.1
550 aa
eif2ak2,  X.tropicalis
eukaryotic translation initiation factor 2-alpha kinase 2
NP_001072537.1
552 aa
pkr3,  X.tropicalis
double-stranded RNA activated protein kinase 3
XP_002933926.1
534 aa
eif2ak2,  D.rerio
eukaryotic translation initiation factor 2-alpha kinase 2
NP_001107942.1
682 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The multiple faces of proteinkinase R in antiviral defense.
Munir M & Berg M. Virulence 4, 85-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
DSRM (cl00054)
  Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eif2ak2 includes H.sapiens EIF2AK2 and R.norvegicus Eif2ak2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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