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HomoloGene:7186. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PSEN1,  H.sapiens
presenilin 1
NP_000012.1
467 aa
PSEN1,  P.troglodytes
presenilin 1
XP_001150037.1
467 aa
PSEN1,  M.mulatta
presenilin 1
XP_001088635.1
467 aa
PSEN1,  C.lupus
presenilin 1
NP_001002943.1
466 aa
PSEN1,  B.taurus
presenilin 1
NP_777146.1
478 aa
Psen1,  M.musculus
presenilin 1
NP_032969.1
467 aa
Psen1,  R.norvegicus
presenilin 1
NP_062036.2
468 aa
PSEN1,  G.gallus
presenilin 1
NP_989494.1
468 aa
psen1,  X.tropicalis
presenilin 1
NP_001027027.1
433 aa
psen1,  D.rerio
presenilin 1
NP_571099.1
456 aa
sel-12,  C.elegans
sel-12
NP_508175.1
444 aa
PS2,  A.thaliana
PS2
NP_180551.1
397 aa
PS1,  A.thaliana
PS1
NP_172346.1
453 aa
Os03g0603700,  O.sativa
Os03g0603700
NP_001173529.1
459 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiomyopathy, dilated, 1U.
Pick disease.
Dementia, frontotemporal.
Alzheimer disease, type 3.
Alzheimer disease, type 3, with spastic paraparesis and apraxia.
Alzheimer disease, type 3, with spastic paraparesis and unusual plaques.



Publications
Articles associated with genes and sequences of this homology group.

Amyloid beta inhibits olfactory bulb activity and the ability to smell.
Alvarado-Martínez R, et al. PLoS One 8, e75745 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_A22B (cl01342)
  Signal peptide peptidase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Psen1 includes H.sapiens PSEN1 and R.norvegicus Psen1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 14 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 10 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (18 transcripts, 14 species)
Liliopsida - monocots (7 transcripts, 6 species)
Coniferopsida - conifers (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

 

 

 

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