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HomoloGene:4550. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PPP5C,  H.sapiens
protein phosphatase 5, catalytic subunit
NP_006238.1
499 aa
PPP5C,  P.troglodytes
protein phosphatase 5, catalytic subunit
XP_512768.2
499 aa
PPP5C,  M.mulatta
protein phosphatase 5, catalytic subunit
XP_001111749.1
499 aa
PPP5C,  C.lupus
protein phosphatase 5, catalytic subunit
XP_005616926.1
490 aa
PPP5C,  B.taurus
protein phosphatase 5, catalytic subunit
NP_001179178.1
499 aa
Ppp5c,  M.musculus
protein phosphatase 5, catalytic subunit
NP_035285.2
499 aa
Ppp5c,  R.norvegicus
protein phosphatase 5, catalytic subunit
NP_113917.1
499 aa
ppp5c,  X.tropicalis
protein phosphatase 5, catalytic subunit
NP_001007891.1
493 aa
ppp5c,  D.rerio
protein phosphatase 5, catalytic subunit
NP_001014372.2
481 aa
PpD3,  D.melanogaster
Protein phosphatase D3
NP_524946.1
520 aa
AgaP_AGAP004151,  A.gambiae
AgaP_AGAP004151
XP_313034.5
500 aa
pph-5,  C.elegans
pph-5
NP_001256849.1
496 aa
PPT1,  S.cerevisiae
PPT1
NP_011639.3
513 aa
KLLA0B10912g,  K.lactis
KLLA0B10912g
XP_452014.1
512 aa
AGOS_AAR083C,  E.gossypii
AGOS_AAR083C
NP_982624.2
506 aa
SPBC3F6.01c,  S.pombe
SPBC3F6.01c
NP_596740.1
473 aa
MGG_06941,  M.oryzae
MGG_06941
XP_003709681.1
478 aa
NCU01433,  N.crassa
NCU01433
XP_955993.1
479 aa
PP5.2,  A.thaliana
PP5.2
NP_565985.1
484 aa
Os05g0204900,  O.sativa
Os05g0204900
NP_001054892.1
483 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.
Golden T, et al. Biochim Biophys Acta 1782, 259-70 (2008).
Protein phosphatase 5 as a negative key regulator of Raf-1 activation.
Shah BH & Catt KJ. Trends Endocrinol Metab 17, 382-4 (2006).
Rac GTPase signaling through the PP5 protein phosphatase.
Gentile S, et al. Proc Natl Acad Sci U S A 103, 5202-6 (2006).
Protein phosphatase 5 is a negative modulator of heat shock factor 1.
Conde R, et al. J Biol Chem 280, 28989-96 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TPR_16 (pfam13432)
  Tetratricopeptide repeat.
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
MPP_superfamily (cl13995)
  metallophosphatase superfamily, metallophosphatase domain.
MPP_superfamily (cl13995)
  metallophosphatase superfamily, metallophosphatase domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ppp5c includes H.sapiens PPP5C and R.norvegicus Ppp5c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (14 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (50 transcripts, 31 species)
Liliopsida - monocots (11 transcripts, 8 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (11 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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