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HomoloGene:56470. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DHFR,  H.sapiens
dihydrofolate reductase
NP_000782.1
187 aa
DHFR,  P.troglodytes
dihydrofolate reductase
XP_001134992.1
187 aa
DHFR,  M.mulatta
dihydrofolate reductase
XP_001099963.2
207 aa
DHFR,  C.lupus
dihydrofolate reductase
XP_003432528.1
191 aa
DHFR,  B.taurus
dihydrofolate reductase
NP_001071351.1
187 aa
Dhfr,  M.musculus
dihydrofolate reductase
NP_034179.1
187 aa
Dhfr,  R.norvegicus
dihydrofolate reductase
NP_569084.1
187 aa
DHFR,  G.gallus
dihydrofolate reductase
NP_001006584.2
190 aa
LOC100486206,  X.tropicalis
dihydrofolate reductase-like
XP_002942406.1
189 aa
dhfr,  D.rerio
dihydrofolate reductase
NP_571850.1
190 aa
Dhfr,  D.melanogaster
Dihydrofolate reductase
NP_732147.1
182 aa
AgaP_AGAP010278,  A.gambiae
AgaP_AGAP010278
XP_319471.3
187 aa
dhfr-1,  C.elegans
dhfr-1
NP_492364.1
189 aa
dfr1,  S.pombe
dfr1
NP_588353.1
461 aa
MGG_10204,  M.oryzae
MGG_10204
XP_003713835.1
232 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
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Publications
Articles associated with genes and sequences of this homology group.

Divergent evolution of protein conformational dynamics in dihydrofolate reductase.
Bhabha G, et al. Nat Struct Mol Biol 20, 1243-9 (2013).
A second target of benzamide riboside: dihydrofolate reductase.
Roussel B, et al. Cancer Biol Ther 13, 1290-8 (2012).
Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Sun S, et al. Acta Biochim Biophys Sin (Shanghai) 43, 957-69 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Abhydrolase_5 (pfam12695)
  Alpha/beta hydrolase family.
DHFR (cl17426)
  Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase. Inhibition of DHFR interrupts thymidilate synthesis and DNA replication, inhibitors of DHFR (such as Methotrexate) are used in cancer chemotherapy. 5,6,7,8-tetrahydrofolate also is involved in glycine, serine, and threonine metabolism and aminoacyl-tRNA biosynthesis.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dhfr includes H.sapiens DHFR and R.norvegicus Dhfr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)

 

 

 

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