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HomoloGene:20128. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

L1CAM,  H.sapiens
L1 cell adhesion molecule
NP_000416.1
1257 aa
L1CAM,  P.troglodytes
L1 cell adhesion molecule
NP_001180609.1
1257 aa
L1CAM,  M.mulatta
L1 cell adhesion molecule
XP_001087861.1
1257 aa
L1CAM,  C.lupus
L1 cell adhesion molecule
XP_549364.2
1256 aa
L1CAM,  B.taurus
L1 cell adhesion molecule
NP_001179364.1
1257 aa
L1cam,  M.musculus
L1 cell adhesion molecule
NP_032504.3
1259 aa
L1cam,  R.norvegicus
L1 cell adhesion molecule
NP_059041.1
1255 aa
L1CAM,  G.gallus
L1 cell adhesion molecule
NP_990484.1
1266 aa
l1cam,  X.tropicalis
L1 cell adhesion molecule
NP_001096185.1
1250 aa
nadl1.2,  D.rerio
neural adhesion molecule L1.2
NP_571436.1
1271 aa
nadl1.1,  D.rerio
neural adhesion molecule L1.1
NP_571458.1
1269 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hydrocephalus with Hirschsprung disease and cleft palate.
CRASH syndrome.
MASA syndrome.
Corpus callosum, partial agenesis of.
Hydrocephalus due to aqueductal stenosis.
Hydrocephalus with congenital idiopathic intestinal pseudoobstruction.



Publications
Articles associated with genes and sequences of this homology group.

L1 cell adhesion molecule signaling is inhibited by ethanol in vivo.
Littner Y, et al. Alcohol Clin Exp Res 37, 383-9 (2013).
Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cells.
Dippel V, et al. J Cancer Res Clin Oncol 139, 107-21 (2013).
The neural adhesion molecule L1CAM confers chemoresistance in human glioblastomas.
Held-Feindt J, et al. Neurochem Int 61, 1183-91 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
IG (smart00409)
  Immunoglobulin.
IG_like (smart00410)
  Immunoglobulin like.
Bravo_FIGEY (pfam13882)
  C-terminal domain of Fibronectin type III.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
Bravo_FIGEY (pfam13882)
  Bravo-like intracellular region.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus L1cam includes H.sapiens L1CAM and R.norvegicus L1cam.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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