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HomoloGene:83226. Gene conserved in Euarchontoglires Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

AIM2,  H.sapiens
absent in melanoma 2
343 aa
AIM2,  P.troglodytes
absent in melanoma 2
343 aa
AIM2,  M.mulatta
absent in melanoma 2
343 aa
Aim2,  M.musculus
absent in melanoma 2
354 aa
Aim2,  R.norvegicus
absent in melanoma 2
356 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA.
Sung MW, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 1081-4 (2012).
The mammalian PYHIN gene family: phylogeny, evolution and expression.
Cridland JA, et al. BMC Evol Biol 12, 140 (2012).
Critical role of AIM2 in Mycobacterium tuberculosis infection.
Saiga H, et al. Int Immunol 24, 637-44 (2012).
Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion.
Kopfnagel V, et al. Exp Dermatol 20, 1027-9 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pyrin (cd08305)
  Pyrin: a protein-protein interaction domain.
HIN (pfam02760)
  HIN-200/IF120x domain.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aim2 includes H.sapiens AIM2 and R.norvegicus Aim2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (4 transcripts, 4 species)




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