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HomoloGene:197. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LIG1,  H.sapiens
ligase I, DNA, ATP-dependent
NP_000225.1
919 aa
LIG1,  P.troglodytes
ligase I, DNA, ATP-dependent
XP_001170212.3
936 aa
LIG1,  M.mulatta
ligase I, DNA, ATP-dependent
XP_002801366.1
975 aa
LIG1,  C.lupus
ligase I, DNA, ATP-dependent
XP_005616432.1
912 aa
LIG1,  B.taurus
ligase I, DNA, ATP-dependent
NP_001096018.1
916 aa
Lig1,  M.musculus
ligase I, DNA, ATP-dependent
NP_001076657.1
932 aa
Lig1,  R.norvegicus
ligase I, DNA, ATP-dependent
NP_001019439.1
913 aa
LOC100911727,  R.norvegicus
DNA ligase 1-like
XP_003748816.2
853 aa
LIG1,  G.gallus
ligase I, DNA, ATP-dependent
XP_003643178.2
818 aa
lig1,  X.tropicalis
ligase I, DNA, ATP-dependent
XP_002941929.1
1040 aa
si:dkeyp-35b8.5,  D.rerio
si:dkeyp-35b8.5
NP_001119860.1
1058 aa
DNA-ligI,  D.melanogaster
DNA ligase I
NP_611843.2
747 aa
AgaP_AGAP009222,  A.gambiae
AgaP_AGAP009222
XP_319999.3
752 aa
lig-1,  C.elegans
lig-1
NP_741625.2
773 aa
CDC9,  S.cerevisiae
CDC9
NP_010117.1
755 aa
KLLA0D12496g,  K.lactis
KLLA0D12496g
XP_453619.1
700 aa
AGOS_ACL155W,  E.gossypii
AGOS_ACL155W
NP_983249.1
697 aa
cdc17,  S.pombe
cdc17
NP_593318.2
768 aa
MGG_06370,  M.oryzae
MGG_06370
XP_003717204.1
896 aa
LIG1,  A.thaliana
LIG1
NP_172293.2
790 aa
AT1G49250,  A.thaliana
AT1G49250
NP_175351.1
657 aa
Os10g0489200,  O.sativa
Os10g0489200
NP_001064917.1
828 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
DNA ligase I deficiency.



Publications
Articles associated with genes and sequences of this homology group.

DNA ligase I, the replicative DNA ligase.
Howes TR & Tomkinson AE. Subcell Biochem 62, 327-41 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DNA_ligase_A_N (pfam04675)
  DNA ligase N terminus.
OBF_DNA_ligase_family (cl08424)
  The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases.
Adenylation_DNA_ligase_like (cl12015)
  Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lig1 includes H.sapiens LIG1 and R.norvegicus Lig1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 10 species)
Mammalia - mammals (12 transcripts, 9 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (27 transcripts, 19 species)
Liliopsida - monocots (9 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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