Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:1731. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LEPR,  H.sapiens
leptin receptor
NP_002294.2
1165 aa
LEPR,  P.troglodytes
leptin receptor
XP_001161937.1
1165 aa
LEPR,  M.mulatta
leptin receptor
NP_001027991.1
1194 aa
LEPR,  C.lupus
leptin receptor
NP_001019805.1
1166 aa
LEPR,  B.taurus
leptin receptor
NP_001012285.2
1165 aa
Lepr,  M.musculus
leptin receptor
NP_666258.2
1162 aa
Lepr,  R.norvegicus
leptin receptor
NP_036728.1
1162 aa
LEPR,  G.gallus
leptin receptor
NP_989654.1
1148 aa
lepr,  X.tropicalis
leptin receptor
NP_001037866.2
1148 aa
lepr,  D.rerio
leptin receptor
NP_001106847.1
1091 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, morbid, with hypogonadism.



Publications
Articles associated with genes and sequences of this homology group.

Retinal proteome alterations in a mouse model of type 2 diabetes.
Ly A, et al. Diabetologia 57, 192-203 (2014).
Suramin: a potential therapy for diabetic nephropathy.
Korrapati MC, et al. PLoS One 8, e73655 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lep_receptor_Ig (pfam06328)
  Ig-like C2-type domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Lep_receptor_Ig (pfam06328)
  Ig-like C2-type domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lepr includes H.sapiens LEPR and R.norvegicus Lepr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

Support Center