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HomoloGene:32441. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MEFV,  H.sapiens
Mediterranean fever
NP_000234.1
781 aa
MEFV,  P.troglodytes
Mediterranean fever
XP_523280.3
781 aa
MEFV,  M.mulatta
Mediterranean fever
XP_001092338.1
786 aa
MEFV,  C.lupus
Mediterranean fever
XP_547161.4
858 aa
LOC529195,  B.taurus
pyrin-like
XP_002697924.3
688 aa
Mefv,  M.musculus
Mediterranean fever
NP_001155263.1
740 aa
Mefv,  R.norvegicus
Mediterranean fever
NP_113822.1
750 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Familial Mediterranean fever.



Publications
Articles associated with genes and sequences of this homology group.

MEFV gene mutations in Henoch-Schönlein purpura.
Altug U, et al. Int J Rheum Dis 16, 347-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pyrin_ASC-like (cd08321)
  Pyrin Death Domain found in ASC.
PRY (pfam13765)
  SPRY-associated domain.
TEX13 (pfam15186)
  Testis-expressed sequence 13 protein family.
BBOX (cl00034)
  B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
SPRY (cl02614)
  SPRY domain.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mefv includes H.sapiens MEFV and R.norvegicus Mefv.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (4 transcripts, 4 species)

 

 

 

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