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HomoloGene:9232. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AAAS,  H.sapiens
achalasia, adrenocortical insufficiency, alacrimia
NP_056480.1
546 aa
AAAS,  P.troglodytes
achalasia, adrenocortical insufficiency, alacrimia
NP_001233360.1
546 aa
AAAS,  C.lupus
achalasia, adrenocortical insufficiency, alacrimia
XP_849797.3
546 aa
AAAS,  B.taurus
achalasia, adrenocortical insufficiency, alacrimia
NP_001068737.1
556 aa
Aaas,  M.musculus
achalasia, adrenocortical insufficiency, alacrimia
NP_700465.2
546 aa
Aaas,  R.norvegicus
achalasia, adrenocortical insufficiency, alacrimia
NP_001100265.1
546 aa
AAAS,  G.gallus
achalasia, adrenocortical insufficiency, alacrimia
XP_003643473.1
451 aa
aaas,  X.tropicalis
achalasia, adrenocortical insufficiency, alacrimia
XP_002936677.1
519 aa
aaas,  D.rerio
achalasia, adrenocortical insufficiency, alacrimia
NP_998390.1
499 aa
CG16892,  D.melanogaster
CG16892
NP_572557.1
466 aa
AgaP_AGAP010685,  A.gambiae
AgaP_AGAP010685
XP_311401.4
210 aa
AT3G56900,  A.thaliana
AT3G56900
NP_191249.2
447 aa
Os11g0132700,  O.sativa
Os11g0132700
NP_001065665.1
443 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Achalasia-addisonianism-alacrimia syndrome.



Publications
Articles associated with genes and sequences of this homology group.

The genetic basis of triple A (Allgrove) syndrome in a Greek family.
Papageorgiou L, et al. Gene 512, 505-9 (2013).
Triple A syndrome: 32 years experience of a single centre (1977-2008).
Milenkovic T, et al. Eur J Pediatr 169, 1323-8 (2010).
Triple A syndrome.
Menon SK, et al. Indian J Pediatr 75, 967 (2008).
Case report of adult-onset Allgrove syndrome.
Gilio F, et al. Neurol Sci 28, 331-5 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aaas includes H.sapiens AAAS and R.norvegicus Aaas.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (25 transcripts, 22 species)
Liliopsida - monocots (9 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

 

 

 

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