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HomoloGene:124. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GALC,  H.sapiens
galactosylceramidase
NP_000144.2
685 aa
GALC,  P.troglodytes
galactosylceramidase
XP_001136291.1
662 aa
GALC,  M.mulatta
galactosylceramidase
NP_001037727.1
669 aa
GALC,  C.lupus
galactosylceramidase
NP_001003238.1
669 aa
GALC,  B.taurus
galactosylceramidase
NP_001192949.1
685 aa
Galc,  M.musculus
galactosylceramidase
NP_032105.2
684 aa
Galc,  R.norvegicus
galactosylceramidase
NP_001005888.1
668 aa
GALC,  G.gallus
galactosylceramidase
XP_421304.3
675 aa
galc,  X.tropicalis
galactosylceramidase
NP_001072270.1
678 aa
galcb,  D.rerio
galactosylceramidase b
NP_998276.1
664 aa
CELE_C29E4.10,  C.elegans
CELE_C29E4.10
NP_498726.3
645 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Krabbe disease.



Publications
Articles associated with genes and sequences of this homology group.

Does galactocerebrosidase activity predict Krabbe phenotype?
Jalal K, et al. Pediatr Neurol 47, 324-9 (2012).
Oxidative stress as a therapeutic target in globoid cell leukodystrophy.
Hawkins-Salsbury JA, et al. Exp Neurol 237, 444-52 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glyco_hydro_59 (pfam02057)
  Glycosyl hydrolase family 59.
Glyco_hydro_59 (pfam02057)
  Glycosyl hydrolase family 59.
Cellulase-like (cl19200)
  Sugar-binding cellulase-like.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Galc includes H.sapiens GALC and R.norvegicus Galc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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