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HomoloGene:1547. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GARS,  H.sapiens
glycyl-tRNA synthetase
NP_002038.2
739 aa
GARS,  P.troglodytes
glycyl-tRNA synthetase
XP_519025.3
739 aa
GARS,  C.lupus
glycyl-tRNA synthetase
XP_003639538.1
749 aa
GARS,  B.taurus
glycyl-tRNA synthetase
NP_001091035.1
739 aa
Gars,  M.musculus
glycyl-tRNA synthetase
NP_851009.2
729 aa
Gars,  R.norvegicus
glycyl-tRNA synthetase
NP_001258068.1
728 aa
GARS,  G.gallus
glycyl-tRNA synthetase
NP_001026681.1
685 aa
gars,  X.tropicalis
glycyl-tRNA synthetase
NP_001007492.1
745 aa
gars,  D.rerio
glycyl-tRNA synthetase
XP_692410.4
761 aa
Aats-gly,  D.melanogaster
Glycyl-tRNA synthetase
NP_001261867.1
765 aa
AgaP_AGAP008604,  A.gambiae
AgaP_AGAP008604
XP_557743.2
703 aa
gars-1,  C.elegans
gars-1
NP_498093.1
742 aa
GRS1,  S.cerevisiae
GRS1
NP_009679.2
667 aa
KLLA0B08932g,  K.lactis
KLLA0B08932g
XP_451926.1
663 aa
AGOS_ADL373W,  E.gossypii
AGOS_ADL373W
NP_983723.1
658 aa
grs1,  S.pombe
grs1
NP_593935.1
652 aa
MGG_06321,  M.oryzae
MGG_06321
XP_003717264.1
726 aa
NCU00405,  N.crassa
NCU00405
XP_957291.1
663 aa
AT1G29880,  A.thaliana
AT1G29880
NP_564337.1
729 aa
Os08g0538000,  O.sativa
Os08g0538000
NP_001062369.1
698 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neuropathy, distal hereditary motor, type V.
Charcot-Marie-Tooth disease, type 2D.



Publications
Articles associated with genes and sequences of this homology group.

Mutational analysis of glycyl-tRNA synthetase (GARS) gene in Hirayama disease.
Blumen SC, et al. Amyotroph Lateral Scler 11, 237-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
glyS_dimeric (TIGR00389)
  glycyl-tRNA synthetase, dimeric type.
class_II_aaRS-like_core (cl00268)
  Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it ...
HGTP_anticodon (cl00266)
  HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
class_II_aaRS-like_core (cl00268)
  Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it ...
S15_NS1_EPRS_RNA-bind (cl00349)
  S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gars includes H.sapiens GARS and R.norvegicus Gars.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 16 species)
Actinopterygii - bony fishes (12 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (34 transcripts, 23 species)
Liliopsida - monocots (11 transcripts, 7 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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