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HomoloGene:74929. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CACNA2D3,  H.sapiens
calcium channel, voltage-dependent, alpha 2/delta subunit 3
NP_060868.2
1091 aa
CACNA2D3,  P.troglodytes
calcium channel, voltage-dependent, alpha 2/delta subunit 3
XP_516539.3
1053 aa
CACNA2D3,  C.lupus
calcium channel, voltage-dependent, alpha 2/delta subunit 3
XP_005633241.1
1071 aa
CACNA2D3,  B.taurus
calcium channel, voltage-dependent, alpha 2/delta subunit 3
NP_001193680.1
1091 aa
Cacna2d3,  M.musculus
calcium channel, voltage-dependent, alpha2/delta subunit 3
NP_033915.1
1091 aa
Cacna2d3,  R.norvegicus
calcium channel, voltage-dependent, alpha2/delta subunit 3
NP_783185.1
1085 aa
CACNA2D3,  G.gallus
calcium channel, voltage-dependent, alpha 2/delta subunit 3
XP_414338.2
1090 aa
cacna2d3,  X.tropicalis
calcium channel, voltage-dependent, alpha 2/delta subunit 3
XP_004914404.1
1262 aa
cacna2d3,  D.rerio
calcium channel, voltage-dependent, alpha 2/delta subunit 3
XP_005172562.1
1074 aa
stj,  D.melanogaster
straightjacket
NP_001246303.1
1271 aa
AgaP_AGAP005490,  A.gambiae
AgaP_AGAP005490
XP_315491.4
1239 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Molecular diversity of the calcium channel alpha2delta subunit.
Klugbauer N, et al. J Neurosci 19, 684-91 (1999).
Genes affecting sensitivity to serotonin in Caenorhabditis elegans.
Schafer WR, et al. Genetics 143, 1219-30 (1996).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
wnt (pfam00110)
  wnt family.
Cache_1 (pfam02743)
  Cache domain.
VWA_N (pfam08399)
  VWA N-terminal.
Cache_1 (pfam02743)
  Cache domain.
VWA_N (pfam08399)
  VWA N-terminal.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cacna2d3 includes H.sapiens CACNA2D3 and R.norvegicus Cacna2d3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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