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HomoloGene:4626. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MERTK,  H.sapiens
c-mer proto-oncogene tyrosine kinase
NP_006334.2
999 aa
MERTK,  P.troglodytes
c-mer proto-oncogene tyrosine kinase
XP_515690.3
999 aa
MERTK,  M.mulatta
c-mer proto-oncogene tyrosine kinase
XP_001086951.1
1001 aa
MERTK,  C.lupus
c-mer proto-oncogene tyrosine kinase
XP_005630494.1
996 aa
MERTK,  B.taurus
c-mer proto-oncogene tyrosine kinase
NP_001178953.2
999 aa
Mertk,  M.musculus
c-mer proto-oncogene tyrosine kinase
NP_032613.1
994 aa
Mertk,  R.norvegicus
c-mer proto-oncogene tyrosine kinase
NP_075232.1
994 aa
MERTK,  G.gallus
c-mer proto-oncogene tyrosine kinase
NP_990319.1
974 aa
mertk,  X.tropicalis
c-mer proto-oncogene tyrosine kinase
XP_002940444.2
986 aa
mertk,  D.rerio
c-mer proto-oncogene tyrosine kinase
XP_002664277.3
952 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinitis pigmentosa, MERTK-related.



Publications
Articles associated with genes and sequences of this homology group.

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
Cook RS, et al. J Clin Invest 123, 3231-42 (2013).
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.
Schlegel J, et al. J Clin Invest 123, 2257-67 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IG_like (smart00410)
  Immunoglobulin like.
Ig (cl11960)
  Immunoglobulin domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mertk includes H.sapiens MERTK and R.norvegicus Mertk.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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