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HomoloGene:449. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PMS1,  H.sapiens
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
NP_000525.1
932 aa
PMS1,  P.troglodytes
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
XP_515987.3
932 aa
PMS1,  M.mulatta
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
XP_001103074.2
770 aa
PMS1,  C.lupus
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
XP_536002.1
930 aa
PMS1,  B.taurus
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
NP_001071449.1
932 aa
Pms1,  M.musculus
postmeiotic segregation increased 1 (S. cerevisiae)
NP_705784.1
917 aa
Pms1,  R.norvegicus
postmeiotic segregation increased 1 (S. cerevisiae)
NP_001009535.1
919 aa
PMS1,  G.gallus
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
NP_001006508.1
916 aa
pms1,  X.tropicalis
PMS1 postmeiotic segregation increased 1
NP_001136373.2
921 aa
pms1,  D.rerio
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
NP_958476.2
896 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal cancer, hereditary nonpolyposis, type 3.



Publications
Articles associated with genes and sequences of this homology group.

Lynch syndrome genes.
Peltomäki P. Fam Cancer 4, 227-32 (2005).
Expression of DNA mismatch repair genes in naevi.
Korabiowska M, et al. In Vivo 13, 251-4 (1999).
Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1.
Yanagisawa Y, et al. Biochem Biophys Res Commun 243, 738-43 (1998).
Biochemistry and genetics of eukaryotic mismatch repair.
Kolodner R. Genes Dev 10, 1433-42 (1996).
Mutation of a mutL homolog in hereditary colon cancer.
Papadopoulos N, et al. Science 263, 1625-9 (1994).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HATPase_c (cl00075)
  Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
TopoII_MutL_Trans (cl02783)
  MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pms1 includes H.sapiens PMS1 and R.norvegicus Pms1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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