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HomoloGene:22566. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FGFR2,  H.sapiens
fibroblast growth factor receptor 2
NP_075259.4
822 aa
FGFR2,  P.troglodytes
fibroblast growth factor receptor 2
XP_001157390.2
723 aa
FGFR2,  C.lupus
fibroblast growth factor receptor 2
NP_001003336.1
707 aa
FGFR2,  B.taurus
fibroblast growth factor receptor 2
NP_001192239.1
839 aa
Fgfr2,  M.musculus
fibroblast growth factor receptor 2
NP_034337.2
840 aa
Fgfr2,  R.norvegicus
fibroblast growth factor receptor 2
NP_001103362.1
840 aa
FGFR2,  G.gallus
fibroblast growth factor receptor 2
NP_990650.1
823 aa
fgfr2,  X.tropicalis
fibroblast growth factor receptor 2
NP_001096326.1
832 aa
fgfr2,  D.rerio
fibroblast growth factor receptor 2
NP_001229933.1
817 aa
btl,  D.melanogaster
breathless
NP_001014583.1
1052 aa
AgaP_AGAP003108,  A.gambiae
AgaP_AGAP003108
XP_562866.4
941 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Apert syndrome.
Saethre-Chotzen syndrome.
Pfeiffer syndrome.
Jackson-Weiss syndrome.
Crouzon syndrome.
Beare-Stevenson cutis gyrata syndrome.
Gastric cancer, somatic.
LADD syndrome.
Craniofacial-skeletal-dermatologic dysplasia.
Craniosynostosis, nonspecific.
Scaphocephaly and Axenfeld-Rieger anomaly.
Antley-Bixler syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Master regulators of FGFR2 signalling and breast cancer risk.
Fletcher MN, et al. Nat Commun 4, 2464 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG_like (smart00410)
  Immunoglobulin like.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgfr2 includes H.sapiens FGFR2 and R.norvegicus Fgfr2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (24 transcripts, 7 species)
Mammalia - mammals (19 transcripts, 14 species)
Aves - birds (5 transcripts, 3 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 4 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (4 transcripts, 1 species)
Hydrozoa - hydrozoans (3 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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