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HomoloGene:37286. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PKLR,  H.sapiens
pyruvate kinase, liver and RBC
NP_000289.1
574 aa
PKLR,  P.troglodytes
pyruvate kinase, liver and RBC
XP_524896.4
562 aa
PKLR,  M.mulatta
pyruvate kinase, liver and RBC
XP_001112902.2
574 aa
PKLR,  C.lupus
pyruvate kinase, liver and RBC
NP_001243191.1
574 aa
PKLR,  B.taurus
pyruvate kinase, liver and RBC
NP_001069644.1
526 aa
Pklr,  M.musculus
pyruvate kinase liver and red blood cell
NP_038659.2
574 aa
Pklr,  R.norvegicus
pyruvate kinase, liver and RBC
NP_036756.3
543 aa
pklr,  D.rerio
pyruvate kinase, liver and RBC
NP_958446.1
538 aa
PYK2,  S.cerevisiae
PYK2
NP_014992.3
506 aa
AT3G04050,  A.thaliana
AT3G04050
NP_187055.1
510 aa
AT3G55650,  A.thaliana
AT3G55650
NP_191124.1
510 aa
AT3G25960,  A.thaliana
AT3G25960
NP_189225.1
497 aa
AT3G55810,  A.thaliana
AT3G55810
NP_191140.1
492 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyruvate kinase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Genetic diversity in human erythrocyte pyruvate kinase.
Berghout J, et al. Genes Immun 13, 98-102 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02461 (PLN02461)
  Probable pyruvate kinase.
Pyruvate_Kinase (cd00288)
  Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pklr includes H.sapiens PKLR and R.norvegicus Pklr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 11 species)
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (4 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

 

 

 

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