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HomoloGene:48145. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RAF1,  H.sapiens
v-raf-1 murine leukemia viral oncogene homolog 1
648 aa
RAF1,  P.troglodytes
v-raf-1 murine leukemia viral oncogene homolog 1
648 aa
RAF1,  M.mulatta
v-raf-1 murine leukemia viral oncogene homolog 1
648 aa
RAF1,  C.lupus
v-raf-1 murine leukemia viral oncogene homolog 1
668 aa
Raf1,  M.musculus
v-raf-leukemia viral oncogene 1
648 aa
Raf1,  R.norvegicus
v-raf-leukemia viral oncogene 1
648 aa
RAF1,  G.gallus
v-raf-1 murine leukemia viral oncogene homolog 1
647 aa
raf1,  X.tropicalis
v-raf-1 murine leukemia viral oncogene homolog 1
638 aa
raf1b,  D.rerio
v-raf-1 murine leukemia viral oncogene homolog 1b
629 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Noonan syndrome 5.
LEOPARD syndrome 2.

Articles associated with genes and sequences of this homology group.

C-RAF mutations confer resistance to RAF inhibitors.
Antony R, et al. Cancer Res 73, 4840-51 (2013).
Endothelial ERK signaling controls lymphatic fate specification.
Deng Y, et al. J Clin Invest 123, 1202-15 (2013).
Two cases of LEOPARD syndrome--RAF1 mutations firstly described in children.
Kuburović V, et al. Turk J Pediatr 53, 687-91 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase (pfam00069)
  Protein kinase domain.
Pkinase (pfam00069)
  Protein kinase domain.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
UBQ (cl00155)
  Ubiquitin-like proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Raf1 includes H.sapiens RAF1 and R.norvegicus Raf1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (19 transcripts, 10 species)
Mammalia - mammals (17 transcripts, 13 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)




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