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HomoloGene:30961. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SHH,  H.sapiens
sonic hedgehog
NP_000184.1
462 aa
SHH,  P.troglodytes
sonic hedgehog
XP_001147185.2
465 aa
SHH,  M.mulatta
sonic hedgehog
XP_001106515.2
465 aa
SHH,  C.lupus
sonic hedgehog
XP_850450.1
461 aa
SHH,  B.taurus
sonic hedgehog
XP_002687031.2
473 aa
Shh,  M.musculus
sonic hedgehog
NP_033196.1
437 aa
Shh,  R.norvegicus
sonic hedgehog
NP_058917.1
437 aa
SHH,  G.gallus
sonic hedgehog
NP_990152.1
425 aa
shh,  X.tropicalis
sonic hedgehog
XP_002932544.2
370 aa
shha,  D.rerio
sonic hedgehog a
NP_571138.1
418 aa
shhb,  D.rerio
sonic hedgehog b
NP_571274.2
416 aa
hh,  D.melanogaster
hedgehog
NP_001034065.1
471 aa
AgaP_AGAP001412,  A.gambiae
AgaP_AGAP001412
XP_321721.5
509 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
A segment polarity type of embryonic lethal. Homozygous embryos have the posterior naked portion of the ventral surface of each segment deleted and replaced by a mirror image of the anterior denticle belts. Embryos appear to lack segmental boundaries. In strong alleles, there is no obvious segmentation; the larvae are approximately 40% the length of the wild-type larvae and there is a lawn of denticles arranged in a number of whorls on the ventral surface as a result of loss of naked cuticle. In intermediate alleles, naked cuticle is also lost from the ventral region, but the lawn of denticles is arranged in segmental arrays in mirror-image symmetry. (See FlyBase for complete description.)

H.sapiens
Coloboma, ocular.
Holoprosencephaly-3.
Solitary median maxillary central incisor.
Polydactyly, preaxial type II.
Triphalangeal thumb, type I.
Triphalangeal thumb-polysyndactyly syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Sonic hedgehog stimulates the recruitment of endothelial progenitor cells.
Podolska K, et al. Med Wieku Rozwoj 17, 151-6 (2013).
Hedgehog on the move: a precise spatial control of Hedgehog dispersion shapes the gradient.
Gradilla AC & Guerrero I. Curr Opin Genet Dev 23, 363-73 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HH_signal (pfam01085)
  Hedgehog amino-terminal signalling domain.
Hint (pfam01079)
  Hint module.
Hint (cd00081)
  Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
Hint (pfam01079)
  Hint module.
HH_signal (pfam01085)
  Hedgehog amino-terminal signalling domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Shh includes H.sapiens SHH and R.norvegicus Shh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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