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HomoloGene:130465. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PRG4,  H.sapiens
proteoglycan 4
1404 aa
PRG4,  P.troglodytes
proteoglycan 4
1039 aa
LOC716849,  M.mulatta
proteoglycan 4-like
552 aa
PRG4,  B.taurus
proteoglycan 4
1195 aa
Prg4,  R.norvegicus
proteoglycan 4
1060 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome.

Articles associated with genes and sequences of this homology group.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.
Waller KA, et al. Proc Natl Acad Sci U S A 110, 5852-7 (2013).
Lubricin in human breast tissue expander capsules.
Cheriyan T, et al. J Biomed Mater Res B Appl Biomater 100, 1961-9 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HX (cd00094)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
Herpes_DNAp_acc (pfam04929)
  Herpes DNA replication accessory factor.
Dicty_REP (pfam05086)
  Dictyostelium (Slime Mold) REP protein.
YqfQ (pfam14181)
  YqfQ-like protein.
Somatomedin_B (cl02508)
  Somatomedin B domain.
ZipA (cl12038)
  ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)

Eurotiomycetes - ascomycetes (1 transcript, 1 species)




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