Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:425. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

F12,  H.sapiens
coagulation factor XII (Hageman factor)
NP_000496.2
615 aa
F12,  P.troglodytes
coagulation factor XII (Hageman factor)
XP_518130.2
615 aa
F12,  M.mulatta
coagulation factor XII (Hageman factor)
XP_001089771.1
615 aa
F12,  C.lupus
coagulation factor XII (Hageman factor)
XP_005619216.1
612 aa
F12,  B.taurus
coagulation factor XII (Hageman factor)
NP_001068587.1
612 aa
F12,  M.musculus
coagulation factor XII (Hageman factor)
NP_067464.2
597 aa
F12,  R.norvegicus
coagulation factor XII (Hageman factor)
NP_001014028.1
603 aa
f12,  X.tropicalis
coagulation factor XII (Hageman factor)
XP_002937000.1
633 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Factor XII deficiency.
Angioedema, hereditary, type III.
Angioneurotic edema, hereditary, X-linked.



Publications
Articles associated with genes and sequences of this homology group.

Hereditary angioedema caused by the p.Thr309Lys mutation in the F12 gene: a multifactorial disease.
Gómez-Traseira C, et al. J Allergy Clin Immunol 132, 986-9.e1-5 (2013).
In vivo roles of factor XII.
Renné T, et al. Blood 120, 4296-303 (2012).
Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.
Papageorgiou PC, et al. Clin Sci (Lond) 122, 581-90 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
FN1 (cl00063)
  Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
FN2 (cl09951)
  Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
EGF (cl19064)
  Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus F12 includes H.sapiens F12 and R.norvegicus F12.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

 

 

 

Support Center