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HomoloGene:1434. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CTNNB1,  H.sapiens
catenin (cadherin-associated protein), beta 1, 88kDa
NP_001091679.1
781 aa
CTNNB1,  P.troglodytes
catenin (cadherin-associated protein), beta 1, 88kDa
XP_001138023.1
781 aa
CTNNB1,  M.mulatta
catenin (cadherin-associated protein), beta 1, 88kDa
XP_002802886.1
781 aa
CTNNB1,  C.lupus
catenin (cadherin-associated protein), beta 1, 88kDa
NP_001131124.1
781 aa
CTNNB1,  B.taurus
catenin (cadherin-associated protein), beta 1, 88kDa
NP_001069609.1
781 aa
Ctnnb1,  M.musculus
catenin (cadherin associated protein), beta 1
NP_001159374.1
781 aa
Ctnnb1,  R.norvegicus
catenin (cadherin associated protein), beta 1
NP_445809.2
781 aa
CTNNB1,  G.gallus
catenin (cadherin-associated protein), beta 1, 88kDa
NP_990412.1
781 aa
ctnnb1,  X.tropicalis
catenin (cadherin-associated protein), beta 1, 88kDa
NP_001016958.1
781 aa
ctnnb1,  D.rerio
catenin (cadherin-associated protein), beta 1
NP_571134.2
780 aa
arm,  D.melanogaster
armadillo
NP_996328.1
843 aa
ARM_ANOGA,  A.gambiae
ARM_ANOGA
XP_309245.5
850 aa
hmp-2,  C.elegans
hmp-2
NP_001252426.1
678 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Embryonic lethal; embryonic segmentation defective by time of germ-band shortening; naked cuticle ordinarily comprizing the posterior two thirds of each segment replaced by mirror-image duplication of the anteriorly situated denticle belt; strong alleles delete first denticle row in abdominal segments. May have dorsal hole in cuticle. Embryonic CNS development quasi normal (Patel et al., 1989). Autonomous at the level of single cells as shown by denticulate clones of homozygous cells in the naked cuticle of abdominal segments in arm/+ embryos (Wieschaus and Riggleman, 1987). (See FlyBase for complete description.)

H.sapiens
Hepatocellular carcinoma.
Colorectal cancer.
Hepatoblastoma.
Ovarian carcinoma, endometrioid type.
Pilomatricoma.
Medulloblastoma.



Publications
Articles associated with genes and sequences of this homology group.

β-Catenin induces T-cell transformation by promoting genomic instability.
Dose M, et al. Proc Natl Acad Sci U S A 111, 391-6 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ARM (cd00020)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
ARM (cl02500)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
HEAT_EZ (cl02500)
  The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ctnnb1 includes H.sapiens CTNNB1 and R.norvegicus Ctnnb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 10 species)
Mammalia - mammals (19 transcripts, 17 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Hyperoartia - vertebrates (4 transcripts, 1 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (20 transcripts, 11 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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