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HomoloGene:7673. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

COL18A1,  H.sapiens
collagen, type XVIII, alpha 1
1516 aa
COL18A1,  P.troglodytes
collagen, type XVIII, alpha 1
1754 aa
COL18A1,  M.mulatta
collagen, type XVIII, alpha 1
1124 aa
Col18a1,  M.musculus
collagen, type XVIII, alpha 1
1527 aa
Col18a1,  R.norvegicus
collagen, type XVIII, alpha 1
1311 aa
COL18A1,  G.gallus
collagen, type XVIII, alpha 1
1344 aa
col18a1,  X.tropicalis
collagen, type XVIII, alpha 1
1301 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Knobloch syndrome.

Articles associated with genes and sequences of this homology group.

Serum endostatin and risk of mortality in the elderly: findings from 2 community-based cohorts.
Ärnlöv J, et al. Arterioscler Thromb Vasc Biol 33, 2689-95 (2013).
Endostatin inhibits Callus remodeling during fracture healing in mice.
Holstein JH, et al. J Orthop Res 31, 1579-84 (2013).
No evidence for locus heterogeneity in Knobloch syndrome.
Aldahmesh MA, et al. J Med Genet 50, 565-6 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TSPN (smart00210)
  Thrombospondin N-terminal -like domains.
DUF959 (pfam06121)
  Domain of Unknown Function (DUF959).
PTX (cl00102)
  Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...
DUF959 (pfam06121)
  Domain of Unknown Function (DUF959).
Endostatin-like (cl00181)
  Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
CRD_FZ (cl02447)
  CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain.
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col18a1 includes H.sapiens COL18A1 and R.norvegicus Col18a1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Anthozoa - anthozoans (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)




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