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HomoloGene:68212. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DDR1,  H.sapiens
discoidin domain receptor tyrosine kinase 1
NP_054699.2
913 aa
DDR1,  P.troglodytes
discoidin domain receptor tyrosine kinase 1
NP_001038967.1
909 aa
DDR1,  M.mulatta
discoidin domain receptor tyrosine kinase 1
NP_001108424.1
875 aa
DDR1,  C.lupus
discoidin domain receptor tyrosine kinase 1
XP_005627171.1
969 aa
DDR1,  B.taurus
discoidin domain receptor tyrosine kinase 1
NP_001069480.2
915 aa
Ddr1,  M.musculus
discoidin domain receptor family, member 1
NP_001185760.1
911 aa
Ddr1,  R.norvegicus
discoidin domain receptor tyrosine kinase 1
NP_001159494.1
910 aa
ddr1,  X.tropicalis
discoidin domain receptor tyrosine kinase 1
XP_004916961.1
946 aa
ddr1,  D.rerio
discoidin domain receptor family, member 1
XP_005158035.1
958 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Oligomerization of DDR1 ECD affects receptor-ligand binding.
Yeung D, et al. J Struct Biol 183, 495-500 (2013).
The discoidin domain receptor 1 gene has a functional A2RE sequence.
Roig B, et al. J Neurochem 120, 408-18 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
FA58C (cl19067)
  Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ddr1 includes H.sapiens DDR1 and R.norvegicus Ddr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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