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HomoloGene:37455. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CASP6,  H.sapiens
caspase 6, apoptosis-related cysteine peptidase
NP_001217.2
293 aa
CASP6,  P.troglodytes
caspase 6, apoptosis-related cysteine peptidase
XP_001136602.2
270 aa
LOC698788,  M.mulatta
caspase-6-like
XP_002804209.1
267 aa
CASP6,  C.lupus
caspase 6, apoptosis-related cysteine peptidase
XP_545022.3
497 aa
CASP6,  B.taurus
caspase 6, apoptosis-related cysteine peptidase
NP_001030496.1
293 aa
Casp6,  M.musculus
caspase 6
NP_033941.3
276 aa
Casp6,  R.norvegicus
caspase 6
NP_001258913.1
277 aa
CASP6,  G.gallus
caspase 6, apoptosis-related cysteine peptidase
NP_990057.1
304 aa
casp6,  X.tropicalis
caspase 6, apoptosis-related cysteine peptidase
NP_001011068.1
304 aa
casp6,  D.rerio
caspase 6, apoptosis-related cysteine peptidase
NP_001018333.1
298 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Caspase-6 activity predicts lower episodic memory ability in aged individuals.
Ramcharitar J, et al. Neurobiol Aging 34, 1815-24 (2013).
Zinc-mediated allosteric inhibition of caspase-6.
Velázquez-Delgado EM & Hardy JA. J Biol Chem 287, 36000-11 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CASc (cl00042)
  Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Casp6 includes H.sapiens CASP6 and R.norvegicus Casp6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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