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HomoloGene:5276. Gene conserved in Amniota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

BRCA1,  H.sapiens
breast cancer 1, early onset
1884 aa
BRCA1,  P.troglodytes
breast cancer 1, early onset
1863 aa
BRCA1,  M.mulatta
breast cancer 1, early onset
1863 aa
BRCA1,  C.lupus
breast cancer 1, early onset
1878 aa
BRCA1,  B.taurus
breast cancer 1, early onset
1849 aa
Brca1,  M.musculus
breast cancer 1
1812 aa
Brca1,  R.norvegicus
breast cancer 1, early onset
1817 aa
BRCA1,  G.gallus
breast cancer 1, early onset
1749 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Breast cancer-1.
Breast-ovarian cancer.
Ovarian cancer.
Papillary serous carcinoma of the peritoneum.

Articles associated with genes and sequences of this homology group.

Identification of germline BRCA1 mutations among breast cancer families in Northeastern Iran.
Kooshyar MM, et al. Asian Pac J Cancer Prev 14, 4339-45 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCT_assoc (pfam12820)
  Serine-rich domain associated with BRCT.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
EIN3 (cl04813)
  Ethylene insensitive 3.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Brca1 includes H.sapiens BRCA1 and R.norvegicus Brca1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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