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HomoloGene:20091. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ITGA6,  H.sapiens
integrin, alpha 6
NP_001073286.1
1091 aa
ITGA6,  P.troglodytes
integrin, alpha 6
XP_515909.3
1091 aa
ITGA6,  M.mulatta
integrin, alpha 6
XP_001086200.2
1091 aa
ITGA6,  C.lupus
integrin, alpha 6
XP_003640224.1
1091 aa
ITGA6,  B.taurus
integrin, alpha 6
NP_001103451.1
1073 aa
Itga6,  M.musculus
integrin alpha 6
NP_001264899.1
1091 aa
Itga6,  R.norvegicus
integrin, alpha 6
NP_446177.1
1073 aa
ITGA6,  G.gallus
integrin, alpha 6
NP_990620.1
1072 aa
itga6,  X.tropicalis
integrin, alpha 6
XP_002934665.2
1095 aa
itga6a,  D.rerio
integrin, alpha 6a
XP_005167467.1
1094 aa
mew,  D.melanogaster
multiple edematous wings
NP_511145.2
1146 aa
AgaP_AGAP000307,  A.gambiae
AgaP_AGAP000307
XP_310816.5
1177 aa
ina-1,  C.elegans
ina-1
NP_499032.1
1139 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Epidermolysis bullosa, junctional, with pyloric stenosis.



Publications
Articles associated with genes and sequences of this homology group.

α6 integrin subunit regulates cerebellar development.
Marchetti G, et al. Cell Adh Migr 7, 325-32 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha (pfam00357)
  Integrin alpha cytoplasmic region.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itga6 includes H.sapiens ITGA6 and R.norvegicus Itga6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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