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HomoloGene:36182. Gene conserved in Amniota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KRT6A,  H.sapiens
keratin 6A
564 aa
KRT6A,  P.troglodytes
keratin 6A
564 aa
LOC100424162,  M.mulatta
keratin, type II cytoskeletal 6A-like
564 aa
KRT6B,  C.lupus
keratin 6B
570 aa
KRT6A,  C.lupus
keratin 6A
570 aa
KRT6A,  B.taurus
keratin 6A
571 aa
KRT6B,  B.taurus
keratin 6B
571 aa
KRT6C,  B.taurus
keratin 6C
571 aa
KRT3,  G.gallus
keratin 3
572 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Pachyonychia congenita, Jadassohn-Lewandowsky type.

Articles associated with genes and sequences of this homology group.

Pachyonychia congenita with laryngeal obstruction.
Haber RM & Drummond D. Pediatr Dermatol 28, 429-32 (2011).
[Keratin k6c mutations in focal palmoplantar keratoderma].
Dereure O. Ann Dermatol Venereol 137, 423-4 (2010).
[The 521 T--> C mutation in the keratin 6A gene in a pedigree with pachyonychia congenita type I].
Yang L, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27, 66-8 (2010).
[Two mutations of the KRT6A gene in Chinese patients with pachyonychia congenita type I].
Bai ZL, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26, 514-7 (2009).
Delayed wound healing in keratin 6a knockout mice.
Wojcik SM, et al. Mol Cell Biol 20, 5248-55 (2000).
Mutation of a type II keratin gene (K6a) in pachyonychia congenita.
Bowden PE, et al. Nat Genet 10, 363-5 (1995).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Filament (pfam00038)
  Intermediate filament protein.
DUF883 (cl01888)
  Bacterial protein of unknown function (DUF883).
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (13 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)




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