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HomoloGene:37306. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LAMA2,  H.sapiens
laminin, alpha 2
NP_001073291.1
3118 aa
LAMA2,  P.troglodytes
laminin, alpha 2
XP_003311525.1
3118 aa
LAMA2,  M.mulatta
laminin, alpha 2
XP_001105600.2
3096 aa
LAMA2,  C.lupus
laminin, alpha 2
XP_003432570.1
3112 aa
LAMA2,  B.taurus
laminin, alpha 2
XP_002690266.1
1469 aa
Lama2,  M.musculus
laminin, alpha 2
NP_032507.2
3118 aa
Lama2,  R.norvegicus
laminin, alpha 2
XP_219866.6
3121 aa
LAMA2,  G.gallus
laminin, alpha 2
XP_419746.4
3161 aa
lama2,  X.tropicalis
laminin, alpha 2
XP_002936356.2
3123 aa
lama2,  D.rerio
laminin, alpha 2
NP_001265728.1
3078 aa
lam-3,  C.elegans
lam-3
NP_492775.2
3102 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Muscular dystrophy, congenital merosin-deficient.
Muscular dystrophy, congenital, due to partial LAMA2 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

LAMA2-Related Muscular Dystrophy
Quijano-Roy S, et al. (1993).
Laminin is required to orient epithelial polarity in the C. elegans pharynx.
Rasmussen JP, et al. Development 139, 2050-60 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HrpB7 (cl09720)
  Bacterial type III secretion protein (HrpB7).
Laminin_II (pfam06009)
  Laminin Domain II.
Laminin_N (pfam00055)
  Laminin N-terminal (Domain VI).
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
Laminin_I (pfam06008)
  Laminin Domain I.
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
PspA (COG1842)
  Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].
COG3334 (COG3334)
  Uncharacterized conserved protein [Function unknown].
COG3883 (COG3883)
  Uncharacterized protein conserved in bacteria [Function unknown].
Laminin_B (cl02548)
  Laminin B (Domain IV).
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
Laminin_I (pfam06008)
  Laminin Domain I.
Laminin_II (pfam06009)
  Laminin Domain II.
ALIX_LYPXL_bnd (pfam13949)
  ALIX V-shaped domain binding to HIV.
COG5314 (cl02193)
  Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion].
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
Prefoldin (cl09111)
  Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
Biotinyl_lipoyl_domains (cl11404)
  Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lama2 includes H.sapiens LAMA2 and R.norvegicus Lama2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (25 transcripts, 13 species)
Aves - birds (4 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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